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U-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study

التفاصيل البيبلوغرافية
العنوان: U-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study
المؤلفون: Kai Zhang, Tianqi Zhang, Qian Yu Lv, Yu Han, Tianyi Cai, Fang ming Gu, Zhao xuan Gu, Jia Yu Zhao, Jia Ying liang, Min Gao, Ya Fang Gao, Rui Hu, Dan Cui, Bo Li, Kexiang Liu
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Blood calcium, In-hospital mortality, Diabetes, Association, Cubic spline function model, Subgroup analysis, Medicine, Science
الوصف: Abstract Previous studies have reported that the significant association between serum calcium and mortality substantially in patients, especially among those with intensive care unit (ICU). And In diabetes mellitus, congestive heart failure (CHF) is a significant comorbidity. We aim to evaluate the association between serum calcium levels and in-hospital mortality among patients with diabetes and congestive heart failure. The participants in this study were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. To scrutinize potential associations between serum calcium levels and in-hospital mortality, a comprehensive analysis encompassing multivariate logistic regression, cubic spline function model, threshold effect analysis, and subgroup analysis was performed. This retrospective cohort study encompassed 7063 patients, among whom the in-hospital mortality stood at 12.2%. In the multivariate logistic regression, adjusted odds ratios (ORs) were contrasted with the reference category Q6 (8.8–9.1 mg/dL) for serum calcium levels and in-hospital mortality. The adjusted ORs for Q1 (≤ 7.7 mg/dL), Q2 (7.7–8 mg/dL), and Q7 (≥ 9.1 mg/dL) were 1.69 (95% CI 1.17–2.44, p = 0.005), 1.62 (95% CI 1.11–2.36, p = 0.013), and 1.57 (95% CI 1.1–2.24, p = 0.012) respectively. The dose–response analysis uncovered a U-shaped relationship between serum calcium levels and in-hospital mortality in diabetic patients with heart failure. Subgroup analyses confirmed result stability notwithstanding the influence of diverse factors. Our investigation revealed a U-shaped correlation between serum calcium levels and in-hospital mortality in diabetes patients with congestive heart failure, pinpointing a significant inflection point at 9.05 mg/dL.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-63603-w
URL الوصول: https://doaj.org/article/a2603fe6c0824a349ac1542c42ccbce2
رقم الأكسشن: edsdoj.2603fe6c0824a349ac1542c42ccbce2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-63603-w