دورية أكاديمية
Immune checkpoint-targeted antibodies: a room for dose and schedule optimization?
| العنوان: | Immune checkpoint-targeted antibodies: a room for dose and schedule optimization? |
|---|---|
| المؤلفون: | Christophe Maritaz, Sophie Broutin, Nathalie Chaput, Aurélien Marabelle, Angelo Paci |
| المصدر: | Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Immunotherapy, Therapeutic antibodies, Dosing interval, Pharmacokinetics, Oncology, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Anti-CTLA-4 and anti-PD-1/PD-L1 immune checkpoint inhibitors are therapeutic monoclonal antibodies that do not target cancer cells but are designed to reactivate or promote antitumor immunity. Dosing and scheduling of these biologics were established according to conventional drug development models, even though the determination of a maximum tolerated dose in the clinic could only be defined for anti-CTLA-4. Given the pharmacology of these monoclonal antibodies, their high interpatient pharmacokinetic variability, the actual clinical benefit as monotherapy that is observed only in a specific subset of patients, and the substantial cost of these treatments, a number of questions arise regarding the selected dose and the dosing interval. This review aims to outline the development of these immunotherapies and considers optimization options that could be used in clinical practice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-8722 |
| Relation: | https://doaj.org/toc/1756-8722 |
| DOI: | 10.1186/s13045-021-01182-3 |
| URL الوصول: | https://doaj.org/article/2613f391c3aa4591b4f5a94f5bbaf65c |
| رقم الأكسشن: | edsdoj.2613f391c3aa4591b4f5a94f5bbaf65c |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17568722 |
|---|---|
| DOI: | 10.1186/s13045-021-01182-3 |