دورية أكاديمية
Identification of Thermophilic Proteins Based on Sequence-Based Bidirectional Representations from Transformer-Embedding Features
| العنوان: | Identification of Thermophilic Proteins Based on Sequence-Based Bidirectional Representations from Transformer-Embedding Features |
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| المؤلفون: | Hongdi Pei, Jiayu Li, Shuhan Ma, Jici Jiang, Mingxin Li, Quan Zou, Zhibin Lv |
| المصدر: | Applied Sciences, Vol 13, Iss 5, p 2858 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Technology LCC:Engineering (General). Civil engineering (General) LCC:Biology (General) LCC:Physics LCC:Chemistry |
| مصطلحات موضوعية: | thermophilic proteins, BERT, machine learning, imbalanced dataset, deep learning, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999 |
| الوصف: | Thermophilic proteins have great potential to be utilized as biocatalysts in biotechnology. Machine learning algorithms are gaining increasing use in identifying such enzymes, reducing or even eliminating the need for experimental studies. While most previously used machine learning methods were based on manually designed features, we developed BertThermo, a model using Bidirectional Encoder Representations from Transformers (BERT), as an automatic feature extraction tool. This method combines a variety of machine learning algorithms and feature engineering methods, while relying on single-feature encoding based on the protein sequence alone for model input. BertThermo achieved an accuracy of 96.97% and 97.51% in 5-fold cross-validation and in independent testing, respectively, identifying thermophilic proteins more reliably than any previously described predictive algorithm. Additionally, BertThermo was tested by a balanced dataset, an imbalanced dataset and a dataset with homology sequences, and the results show that BertThermo was with the best robustness as comparied with state-of-the-art methods. The source code of BertThermo is available. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3417 |
| Relation: | https://www.mdpi.com/2076-3417/13/5/2858; https://doaj.org/toc/2076-3417 |
| DOI: | 10.3390/app13052858 |
| URL الوصول: | https://doaj.org/article/aec2668785a6425fbf53cb813ed51093 |
| رقم الأكسشن: | edsdoj.2668785a6425fbf53cb813ed51093 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763417 |
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| DOI: | 10.3390/app13052858 |