ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

التفاصيل البيبلوغرافية
العنوان:	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
المؤلفون:	Mike R. Wilson, Jake J. Reske, Jeanne Holladay, Genna E. Wilber, Mary Rhodes, Julie Koeman, Marie Adams, Ben Johnson, Ren-Wei Su, Niraj R. Joshi, Amanda L. Patterson, Hui Shen, Richard E. Leach, Jose M. Teixeira, Asgerally T. Fazleabas, Ronald L. Chandler
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-11403-6
URL الوصول:	https://doaj.org/article/266dcb657cd34fc29c11bd4ed2e4f504
رقم الأكسشن:	edsdoj.266dcb657cd34fc29c11bd4ed2e4f504
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-11403-6