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Assessment of diffusion-weighted MRI in predicting response to neoadjuvant chemotherapy in breast cancer patients

التفاصيل البيبلوغرافية
العنوان: Assessment of diffusion-weighted MRI in predicting response to neoadjuvant chemotherapy in breast cancer patients
المؤلفون: Nathalie A. Hottat, Dominique A. Badr, Sophie Lecomte, Tatiana Besse-Hammer, Jacques C. Jani, Mieke M. Cannie
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract To compare region of interest (ROI)-apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) measurements and Ki-67 proliferation index before and after neoadjuvant chemotherapy (NACT) for breast cancer. 55 women were enrolled in this prospective single-center study, with a final population of 47 women (49 cases of invasive breast cancer). ROI-ADC measurements were obtained on MRI before and after NACT and were compared to histological findings, including the Ki-67 index in the whole study population and in subgroups of “pathologic complete response” (pCR) and non-pCR. Nineteen percent of women experienced pCR. There was a significant inverse correlation between Ki-67 index and ROI-ADC before NACT (r = − 0.443, p = 0.001) and after NACT (r = − 0.614, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-27787-x
URL الوصول: https://doaj.org/article/26b6f90046c44f119eebf5fd1f105899
رقم الأكسشن: edsdoj.26b6f90046c44f119eebf5fd1f105899
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-023-27787-x