دورية أكاديمية
Assessment of diffusion-weighted MRI in predicting response to neoadjuvant chemotherapy in breast cancer patients
العنوان: | Assessment of diffusion-weighted MRI in predicting response to neoadjuvant chemotherapy in breast cancer patients |
---|---|
المؤلفون: | Nathalie A. Hottat, Dominique A. Badr, Sophie Lecomte, Tatiana Besse-Hammer, Jacques C. Jani, Mieke M. Cannie |
المصدر: | Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023) |
بيانات النشر: | Nature Portfolio, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Abstract To compare region of interest (ROI)-apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) measurements and Ki-67 proliferation index before and after neoadjuvant chemotherapy (NACT) for breast cancer. 55 women were enrolled in this prospective single-center study, with a final population of 47 women (49 cases of invasive breast cancer). ROI-ADC measurements were obtained on MRI before and after NACT and were compared to histological findings, including the Ki-67 index in the whole study population and in subgroups of “pathologic complete response” (pCR) and non-pCR. Nineteen percent of women experienced pCR. There was a significant inverse correlation between Ki-67 index and ROI-ADC before NACT (r = − 0.443, p = 0.001) and after NACT (r = − 0.614, p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2045-2322 |
Relation: | https://doaj.org/toc/2045-2322 |
DOI: | 10.1038/s41598-023-27787-x |
URL الوصول: | https://doaj.org/article/26b6f90046c44f119eebf5fd1f105899 |
رقم الأكسشن: | edsdoj.26b6f90046c44f119eebf5fd1f105899 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20452322 |
---|---|
DOI: | 10.1038/s41598-023-27787-x |