دورية أكاديمية
PSMA Receptor-Based PET-CT: The Basics and Current Status in Clinical and Research Applications
| العنوان: | PSMA Receptor-Based PET-CT: The Basics and Current Status in Clinical and Research Applications |
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| المؤلفون: | Aadil Adnan, Sandip Basu |
| المصدر: | Diagnostics, Vol 13, Iss 1, p 158 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | 68Ga-PSMA, FDG, PET-CT, 177Lu-PSMA-617, prostate cancer, metastatic castration-resistant prostate carcinoma, Medicine (General), R5-920 |
| الوصف: | Prostate-specific membrane antigen (PSMA) is a 100 kD, 750 amino acid (AA) long type II transmembrane glycoprotein that has a short N-terminal intracellular domain with 19 AA, 24 AA transmembrane proteins and a large C-terminal extracellular domain with 707 AA. PSMA has been mapped to chromosome 11p 11-12 in the region of the folate hydrolase gene (FOLH1) and has no known natural ligand. The protein possesses enzymatic activity—glutamate carboxypeptidase II (GCP-II)—and is thought to have role in folate uptake (FOLH1 gene). ‘PSMA’ expression, although significantly up-regulated in prostate carcinoma (more in high-risk and aggressive variants), is not exclusive for it and is noted in various other benign and malignant conditions, especially in the neovasculature. Currently, PSMA PET-CT is approved for high-risk and biochemically recurrent prostate carcinoma (PCa), and in patient selection for PSMA based theranostics. This review aims to highlight the clinical evolution of the PSMA molecule and PSMA PET-CT as a diagnostic modality, various indications of PSMA PET-CT, the appropriateness criteria for its use, pitfalls and artefacts, and other uses of PSMA PET apart from prostate carcinoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13010158 2075-4418 |
| Relation: | https://www.mdpi.com/2075-4418/13/1/158; https://doaj.org/toc/2075-4418 |
| DOI: | 10.3390/diagnostics13010158 |
| URL الوصول: | https://doaj.org/article/26e1c5c3c16342808117d78354efb6e2 |
| رقم الأكسشن: | edsdoj.26e1c5c3c16342808117d78354efb6e2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13010158 20754418 |
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| DOI: | 10.3390/diagnostics13010158 |