دورية أكاديمية
Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy
| العنوان: | Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy |
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| المصدر: | Клиническая и экспериментальная тиреоидология, Vol 9, Iss 3, Pp 51-55 (2013) |
| بيانات النشر: | Endocrinology Research Centre, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | pparg, pro12ala, c1431t, thyroid eye disease, endocrine ophthalmopathy, graves’ ophthalmopathy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals. Identified polymorphisms Pro12Ala and C1431T PPARγby PCR. Results. In more common TEO homozygous genotypes Pro/Pro and Ala/Ala (χ 2 = 6,035, p = 0.049) and allele Ala (χ 2 = 15,062, p 0,001) polymorphism Pro12Ala; geno types C/C and T/T (χ 2 = 28,34, p 0,001), the allele C (χ 2 = 15,06, p 0,001) polymorphism C1431T PPARγ, than in the control. The relative risk of TEO in the Ala/Ala genotype of 1.73 (95% CI, 1.45–2.08), with C/T genotype of 0.61 (95% CI, 0.39–0.96). The odds ratio for C/T genotype in patients with TEO 0.33 (95% CI, 0.13–0.82). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1995-5472 2310-3787 |
| Relation: | https://cet-endojournals.ru/ket/article/viewFile/6364/4210; https://doaj.org/toc/1995-5472; https://doaj.org/toc/2310-3787 |
| DOI: | 10.14341/ket20139351-55 |
| URL الوصول: | https://doaj.org/article/274f756741bd483aa7ba87d5f06e93b7 |
| رقم الأكسشن: | edsdoj.274f756741bd483aa7ba87d5f06e93b7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19955472 23103787 |
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| DOI: | 10.14341/ket20139351-55 |