التفاصيل البيبلوغرافية
العنوان:
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
المؤلفون:
Patty Sachamitr , Jolene C. Ho , Felipe E. Ciamponi , Wail Ba-Alawi , Fiona J. Coutinho , Paul Guilhamon , Michelle M. Kushida , Florence M. G. Cavalli , Lilian Lee , Naghmeh Rastegar , Victoria Vu , María Sánchez-Osuna , Jasmin Coulombe-Huntington , Evgeny Kanshin , Heather Whetstone , Mathieu Durand , Philippe Thibault , Kirsten Hart , Maria Mangos , Joseph Veyhl , Wenjun Chen , Nhat Tran , Bang-Chi Duong , Ahmed M. Aman , Xinghui Che , Xiaoyang Lan , Owen Whitley , Olga Zaslaver , Dalia Barsyte-Lovejoy , Laura M. Richards , Ian Restall , Amy Caudy , Hannes L. Röst , Zahid Quyoom Bonday , Mark Bernstein , Sunit Das , Michael D. Cusimano , Julian Spears , Gary D. Bader , Trevor J. Pugh , Mike Tyers , Mathieu Lupien , Benjamin Haibe-Kains , H. Artee Luchman , Samuel Weiss , Katlin B. Massirer , Panagiotis Prinos , Cheryl H. Arrowsmith , Peter B. Dirks
المصدر:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
بيانات النشر:
Nature Portfolio, 2021.
سنة النشر:
2021
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-021-21204-5
URL الوصول:
https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd
رقم الأكسشن:
edsdoj.276d7ef43841fc91a953ffc3d02ecd
قاعدة البيانات:
Directory of Open Access Journals
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