دورية أكاديمية
Whole-Genome Sequencing to Detect Numerous Campylobacter jejuni Outbreaks and Match Patient Isolates to Sources, Denmark, 2015–2017
| العنوان: | Whole-Genome Sequencing to Detect Numerous Campylobacter jejuni Outbreaks and Match Patient Isolates to Sources, Denmark, 2015–2017 |
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| المؤلفون: | Katrine G. Joensen, Kristoffer Kiil, Mette R. Gantzhorn, Birgitte Nauerby, Jørgen Engberg, Hanne M. Holt, Hans L. Nielsen, Andreas M. Petersen, Katrin G. Kuhn, Gudrun Sandø, Steen Ethelberg, Eva M. Nielsen |
| المصدر: | Emerging Infectious Diseases, Vol 26, Iss 3, Pp 523-532 (2020) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Campylobacter, bacteria, whole-genome sequencing, epidemiology, outbreaks, core-genome multilocus sequence typing, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | In industrialized countries, the leading cause of bacterial gastroenteritis is Campylobacter jejuni. However, outbreaks are rarely reported, which may reflect limitations of surveillance, for which molecular typing is not routinely performed. To determine the frequency of genetic clusters among patients and to find links to concurrent isolates from poultry meat, broiler chickens, cattle, pigs, and dogs, we performed whole-genome sequencing on 1,509 C. jejuni isolates from 774 patients and 735 food or animal sources in Denmark during 2015–2017. We found numerous clusters; 366/774 (47.3%) clinical isolates formed 104 clusters of >2 isolates. A total of 41 patient clusters representing 199/366 (54%) patients matched a potential source, primarily domestic chickens/broilers. This study revealed serial outbreaks and numerous matches to concurrent food and animal isolates and highlighted the potential of whole-genome sequencing for improving routine surveillance of C. jejuni by enhancing outbreak detection, source tracing, and potentially prevention of human infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/26/3/19-0947_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2603.190947 |
| URL الوصول: | https://doaj.org/article/e2776eb04fc64ca0b28c14324d09c5ca |
| رقم الأكسشن: | edsdoj.2776eb04fc64ca0b28c14324d09c5ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2603.190947 |