دورية أكاديمية
Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
| العنوان: | Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells |
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| المؤلفون: | Philippe Pasero, Hélène Tourrière |
| المصدر: | Molecular & Cellular Oncology, Vol 6, Iss 4 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | replication fork stability, replication checkpoint, claspin, timeless, replication stress, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote fork progression in a checkpoint-independent manner. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| Relation: | https://doaj.org/toc/2372-3556 |
| DOI: | 10.1080/23723556.2019.1607455 |
| URL الوصول: | https://doaj.org/article/27792d3ae0d54381bb334da5134ea595 |
| رقم الأكسشن: | edsdoj.27792d3ae0d54381bb334da5134ea595 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2019.1607455 |