دورية أكاديمية
أعرض في EDS

Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint

التفاصيل البيبلوغرافية
العنوان: Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint
المؤلفون: Jai-Hong Cheng, Ke-Tien Yen, Wen-Yi Chou, Shun-Wun Jhan, Shan-Ling Hsu, Jih-Yang Ko, Ching-Jen Wang, Chun-En Aurea Kuo, Szu-Ying Wu, Tsai-Chin Hsu, Chieh-Cheng Hsu
المصدر: Pharmaceuticals, Vol 14, Iss 4, p 318 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Pharmacy and materia medica
مصطلحات موضوعية: adipose-derived mesenchymal stem cells, shockwave, osteoarthritis, extracellular matrix factors, bone morphogenetic protein, Medicine, Pharmacy and materia medica, RS1-441
الوصف: Adipose-derived mesenchymal stem cells (ADSCs) and shockwave (SW) therapy have been shown to exert a chondroprotective effect for osteoarthritis (OA). The results of this study demonstrated that autologous ADSCs had dose-dependent and synergistic effects with SW therapy (0.25 mJ/mm2 with 800 impulses) in OA rat knee joint. Autologous, high-dose 2 × 106 ADSCs (ADSC2 group) combined with SW therapy significantly increased the bone volume, trabecular thickness, and trabecular number among in the treatment groups. ADSC2 combined with SW therapy significantly reduced the synovitis score and OARSI score in comparison with other treatments. In the analysis of inflammation-induced extracellular matrix factors of the articular cartilage in OA, the results displayed that ADSC2 combined with SW therapy had a greater than other treatments in terms of reducing tumor necrosis factor-inducible gene (TSG)-6 and proteoglycan (PRG)-4, in addition to increasing tissue inhibitor matrix metalloproteinase (TIMP)-1 and type II collagen. Furthermore, ADSC2 combined with SW therapy significantly reduced the expression of inflammation-induced bone morphogenetic protein (BMP)-2 and BMP-6. Therefore, the results demonstrated that ADSC2 combined with SW therapy had a synergistic effect to ameliorate osteoarthritic pathological factors in OA joints.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1424-8247
Relation: https://www.mdpi.com/1424-8247/14/4/318; https://doaj.org/toc/1424-8247
DOI: 10.3390/ph14040318
URL الوصول: https://doaj.org/article/27b2934900df4ba28635611669d14208
رقم الأكسشن: edsdoj.27b2934900df4ba28635611669d14208
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14248247
DOI:10.3390/ph14040318