دورية أكاديمية
Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function
| العنوان: | Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function |
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| المؤلفون: | Daniel W. Nuno, Kathryn G. Lamping |
| المصدر: | Journal of Diabetes Research, Vol 2019 (2019) |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Sphingolipids, modified by dietary fatty acids, are integral components of plasma membrane and caveolae that are also vasoactive compounds. We hypothesized that dietary fatty acid saturation affects vasoconstriction to sphingosine-1-phosphate (S1P) through caveolar regulation of rho kinase. Wild type (WT) and caveolin-1-deficient (cav-1 KO) mice which lack vascular caveolae were fed a low-fat diet (LF), 60% high-saturated fat diet (lard, HF), or 60% fat diet with equal amounts of lard and n-3 polyunsaturated menhaden oil (MO). Weight gain of WT on HF and MO diets was similar while markedly blunted in cav-1 KO. Neither high-fat diet affected the expression of cav-1, rho, or rho kinase in arteries from WT. In cav-1 KO, MO increased the vascular expression of rho but had no effect on rho kinase. HF had no effect on rho or rho kinase expression in cav-1 KO. S1P produced a concentration-dependent constriction of gracilis arteries from WT on LF that was reduced with HF and restored to normal with MO. Constriction to S1P was reduced in cav-1 KO and no longer affected by a high-saturated fat diet. Inhibition of rho kinase which reduced constriction to PE independent of diet in arteries from WT and cav-1 KO only reduced constriction to S1P in arteries from WT fed MO. The data suggest that dietary fatty acids modify vascular responses to S1P by a caveolar-dependent mechanism which is enhanced by dietary n-3 polyunsaturated fats. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-6745 2314-6753 |
| Relation: | https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753 |
| DOI: | 10.1155/2019/2354274 |
| URL الوصول: | https://doaj.org/article/28184833e49449cc9bb9c753e1ab09e3 |
| رقم الأكسشن: | edsdoj.28184833e49449cc9bb9c753e1ab09e3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23146745 23146753 |
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| DOI: | 10.1155/2019/2354274 |