دورية أكاديمية
Analysis of clinical features, serologic and cerebrospinal fluid tests in patients with neurosyphilis at different stages
| العنوان: | Analysis of clinical features, serologic and cerebrospinal fluid tests in patients with neurosyphilis at different stages |
|---|---|
| المؤلفون: | Bao-jie WANG, Chun-juan WANG, Hao SUN, Shou-gang GUO |
| المصدر: | Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 16, Iss 7, Pp 404-410 (2016) |
| بيانات النشر: | Tianjin Huanhu Hospital, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Neurosyphilis, Serologic tests, Cerebrospinal fluid, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Objective To summarize the clinical features, serologic, cerebrospinal fluid (CSF) tests in patients with neurosyphilis at different stages. Methods A retrospective analysis was made on the clinical features, imaging, serologic and CSF tests, treatment and prognosis of 12 cases diagnosed as neurosyphilis. In those cases, 5 cases were early-stage neurosyphilis, including 4 syphilitic meningitis (meningomyelitis) and one meningovascular syphilis; 7 cases were late-stage neurosyphilis, all of whom were general paresis. Results The serum Treponema pallidum antibody (TP-Ab) and rapid plasma regain (RPR) tests were positive in all 12 cases. The CSF TP-Ab tests of 12 cases were all positive and CSF RPR tests were positive in 9 cases. In 5 cases of early-stage neurosyphilis, one case had elevated intracranial pressure (ICP), 3 cases presented with elevated white blood cell (WBC), 4 cases had elevated protein concentration. In 7 cases of late-stage neurosyphilis, one case had elevated ICP, 7 cases presented with elevated WBC and protein concentration. CSF cytology showed lymphocyte reaction, mainly small lymphocytes. All cases were treated with different doses of intravenous penicillin or ceftriaxone sodium by intramuscular injection, among whom 8 cases presented improved neuropsychiatric symptoms, while 4 cases had no significant improvement. Conclusions Neurosyphilis is easy to be misdiagnosed because of various styles of onset and nontypical clinical manifestations. A definite diagnosis depends on clinical manifestations and serologic and CSF examinations. Early diagnosis and standard treatment is essential for improving prognosis and reducing complications. DOI: 10.3969/j.issn.1672-6731.2016.07.005 |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 1672-6731 |
| Relation: | http://www.cjcnn.org/index.php/cjcnn/article/view/1424; https://doaj.org/toc/1672-6731 |
| URL الوصول: | https://doaj.org/article/28500acbe96e431286d5a90a1ecfd219 |
| رقم الأكسشن: | edsdoj.28500acbe96e431286d5a90a1ecfd219 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16726731 |
|---|