دورية أكاديمية
Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility
| العنوان: | Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility |
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| المؤلفون: | Jai Y Yu, Kenneth Kay, Daniel F Liu, Irene Grossrubatscher, Adrianna Loback, Marielena Sosa, Jason E Chung, Mattias P Karlsson, Margaret C Larkin, Loren M Frank |
| المصدر: | eLife, Vol 6 (2017) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | hippocampus, prefrontal cortex, sharp wave-ripple, memory, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | While ongoing experience proceeds continuously, memories of past experience are often recalled as episodes with defined beginnings and ends. The neural mechanisms that lead to the formation of discrete episodes from the stream of neural activity patterns representing ongoing experience are unknown. To investigate these mechanisms, we recorded neural activity in the rat hippocampus and prefrontal cortex, structures critical for memory processes. We show that during spatial navigation, hippocampal CA1 place cells maintain a continuous spatial representation across different states of motion (movement and immobility). In contrast, during sharp-wave ripples (SWRs), when representations of experience are transiently reactivated from memory, movement- and immobility-associated activity patterns are most often reactivated separately. Concurrently, distinct hippocampal reactivations of movement- or immobility-associated representations are accompanied by distinct modulation patterns in prefrontal cortex. These findings demonstrate a continuous representation of ongoing experience can be separated into independently reactivated memory representations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/27621; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.27621 |
| URL الوصول: | https://doaj.org/article/a28740a4b446409fb68ab204b9e97b38 |
| رقم الأكسشن: | edsdoj.28740a4b446409fb68ab204b9e97b38 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.27621 |