دورية أكاديمية
BRD7 deficiency leads to the development of obesity and hyperglycemia
| العنوان: | BRD7 deficiency leads to the development of obesity and hyperglycemia |
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| المؤلفون: | Junsik M. Lee, Yoo Kim, Mario Andrés Salazar Hernández, Youngah Han, Renyan Liu, Sang Won Park |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | Nature Portfolio, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Obesity is a debilitating disease that has become a global epidemic. Although progress is being made, the underlying molecular mechanism by which obesity develops still remains elusive. Recently, we reported that the expression levels of bromodomain-containing protein 7 (BRD7) are significantly reduced in the liver of obese mice. However, it is not clear whether decreased levels of hepatic BRD7 are directly associated with the development of obesity and disturbance in glucose homeostasis. Here, using heterozygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report that reduced BRD7 levels lead to increased weight gain with little effect on glucose metabolism. On the other hand, upregulating BRD7 in the liver starting at an early age protects mice from gaining excessive weight and developing glucose intolerance and insulin resistance when challenged with a high-fat diet. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-019-41713-0 |
| URL الوصول: | https://doaj.org/article/da28870084354b9f9a1466d78d0b40ca |
| رقم الأكسشن: | edsdoj.28870084354b9f9a1466d78d0b40ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-019-41713-0 |