دورية أكاديمية
OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients
| العنوان: | OPN Gene Polymorphism and the Serum OPN Levels Confer the Susceptibility and Prognosis of Ischemic Stroke in Chinese Patients |
|---|---|
| المؤلفون: | Meng Jing, Baoxin Li, Xuwei Hou, Jayaram Shoba, Changyu Li, Hongsheng Liang, Xiangtong Zhang, Enzhong Liu, Baofeng Yang, Xiangxi Meng |
| المصدر: | Cellular Physiology and Biochemistry, Vol 32, Iss 6, Pp 1798-1807 (2013) |
| بيانات النشر: | Cell Physiol Biochem Press GmbH & Co KG, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | Prognosis, Osteopontin, Ischemic stroke, Susceptibility, Chinese, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | Aim: To investigate the association of Osteopontin (OPN) gene polymorphism and serum thrombin-cleaved OPN level with the susceptibility to ischemic stroke (IS) and its prognosis. Methods: A total of 377 patients with IS and 551 healthy individuals were recruited. The OPN gene polymorphisms at -156 G>GG, -443 C>T and -66 T>G were genotyped. Serum full-length and the thrombin-cleaved OPN were determined. Results: We found that only the -443 C>T polymorphism was significantly associated with the susceptibility to IS. The -443 CC represented a near 2 time higher risk for IS incidence than TT carriers. Also, the -443 CC genotype had significantly poorer outcome and they significantly had higher occurrence for bad recovery as determined by modified Rankin Scale (mRS) (OR=2.18, p=0.043) and Barthel Index (BI) (OR=2.12, p=0.05). The mean serum thrombin-cleaved OPN level in IS group were significantly higher than that in control group. ROC analysis showed that the thrombin-cleaved OPN level (cut-off value, 166.8 ng/ml) can discriminate IS patients from controls with a specificity of 86.3% and a sensitivity of 57.7%. The serum thrombin-cleaved OPN was significantly associated with the clinical outcome at 12 months after discharge from hospital. Conclusion: These results suggest that the -443 C>T polymorphism of OPN gene and serum thrombin-cleaved OPN can be used as a biomarker for the susceptibility and prognosis of IS patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1015-8987 1421-9778 00035661 |
| Relation: | http://www.karger.com/Article/FullText/356613; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778 |
| DOI: | 10.1159/000356613 |
| URL الوصول: | https://doaj.org/article/d288f3c0e5b946d58ac8ce6abdb7a8d0 |
| رقم الأكسشن: | edsdoj.288f3c0e5b946d58ac8ce6abdb7a8d0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10158987 14219778 00035661 |
|---|---|
| DOI: | 10.1159/000356613 |