دورية أكاديمية
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons
| العنوان: | Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons |
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| المؤلفون: | Théodore Grenier, Jessika Consuegra, Mariana G Ferrarini, Houssam Akherraz, Longwei Bai, Yves Dusabyinema, Isabelle Rahioui, Pedro Da Silva, Benjamin Gillet, Sandrine Hughes, Cathy I Ramos, Renata C Matos, François Leulier |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | symbiosis, Lactobacillus, GCN2, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Symbiotic bacteria interact with their host through symbiotic cues. Here, we took advantage of the mutualism between Drosophila and Lactiplantibacillus plantarum (Lp) to investigate a novel mechanism of host-symbiont interaction. Using chemically defined diets, we found that association with Lp improves the growth of larvae-fed amino acid-imbalanced diets, even though Lp cannot produce the limiting amino acid. We show that in this context Lp supports its host’s growth through a molecular dialogue that requires functional operons encoding ribosomal and transfer RNAs (r/tRNAs) in Lp and the general control nonderepressible 2 (GCN2) kinase in Drosophila’s enterocytes. Our data indicate that Lp’s r/tRNAs are packaged in extracellular vesicles and activate GCN2 in a subset of larval enterocytes, a mechanism necessary to remodel the intestinal transcriptome and ultimately to support anabolic growth. Based on our findings, we propose a novel beneficial molecular dialogue between host and microbes, which relies on a non-canonical role of GCN2 as a mediator of non-nutritional symbiotic cues encoded by r/tRNA operons. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/76584; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.76584 |
| URL الوصول: | https://doaj.org/article/2892f1c0218a4a9b835e34884fc61204 |
| رقم الأكسشن: | edsdoj.2892f1c0218a4a9b835e34884fc61204 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.76584 |