دورية أكاديمية
Synthesis and Characterization of Some New Thiazine , Azetidine and Thiazolidine Compounds Containing 1,3,4Thiadiazole Moiety And Their Antibacterial Study
| العنوان: | Synthesis and Characterization of Some New Thiazine , Azetidine and Thiazolidine Compounds Containing 1,3,4Thiadiazole Moiety And Their Antibacterial Study |
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| المؤلفون: | Ali H. Samir, Khalid F. Ali, Ruwaidah S. Saeed |
| المصدر: | Ibn Al-Haitham Journal for Pure and Applied Sciences, Vol 27, Iss 3 (2017) |
| بيانات النشر: | University of Baghdad, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | 1,3,4-Thiadiazole , Thiazine-4-one, Azetidine-2-one , Thiazolidine-4-one, Science |
| الوصف: | 2-amino-5-mercapto-1,3,4-thiadiazole [I] were prepared by the cyclization of thiosemecarbazide with carbon disulphide and anhydrous sodium carbonate in ethanol as a solvent. The reaction of compound [I] with alkyl halides yielded 2- amino-5-thioalkyl-1,3,4- thiadiazole [II] and [III] . Compound [II] and [III] were reacted with different aromatic aldehydes to yieled 2-[(substituted benzyliden ) amino] -5- thioalkyl-1,3,4- thiadiazole [IV]a-c , [V]a-d and [VI]a-d . Schiff ,s bases [IV]a-c , [V]a-d and [VI]a-d were found to react with 2mercapto benzoic acid in the triethyl amine to give 3-[ 5-( alkylthio) -1,3,4- thiadiazol-2-yl] 2,3- dihydro- 2- (aryl) benzo [e] [1,3] thiazine -4-one [VII]a-c and [VIII]a . The Schiff ,s bases reacted with chloro acetyl chloride in the triethyl amine to give 3-chloro-1-(5-alkylthio)-1,3,4thiadiazole-2-yl)-4-(aryl)azetidine-2-one[IX]a,b , [X]c and [XI]c,d .Also Schiff ,s bases reacted with 2-mercapto acetic acid in dry benzene to give 3-(5-mercapto-1,3,4-thiadiazole-2-yl)-2(aryl)thiazolidine-4-one[XII]a,c ,[XIII]d and [XIV]]c,d. The structures of the newly synthesized compounds were confirmed by physical properties and spectral (UV-Vis , FT-IR and 1H-NMR) analysis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1609-4042 2521-3407 |
| Relation: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/302; https://doaj.org/toc/1609-4042; https://doaj.org/toc/2521-3407 |
| URL الوصول: | https://doaj.org/article/28b3c20895fa4e72afd94ba8e7fe1896 |
| رقم الأكسشن: | edsdoj.28b3c20895fa4e72afd94ba8e7fe1896 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16094042 25213407 |
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