دورية أكاديمية
Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin
| العنوان: | Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin |
|---|---|
| المؤلفون: | Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu, Siqian Wang |
| المصدر: | Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-15 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Curcumin, Iron overload, Bone marrow damage, Autophagy, Mitochondrial ROS, Cytology, QH573-671 |
| الوصف: | Abstract Background Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcumin has been reported to protect against iron overload-induced bone marrow damage through an as-yet-unknown mechanism. Methods We established iron overload cell and mouse models. Mitochondrial reactive oxygen species (mROS) levels, autophagy levels and the SIRT3/SOD2 pathway were examined in the models and in the bone marrow of patients with iron overload. Results Iron overload was shown to depress haematogenesis and induce mitochondrion-derived superoxide anion-dependent autophagic cell death. Iron loading decreased SIRT3 protein expression, promoted an increase in SOD2, and led to the elevation of mROS. Overexpression of SIRT3 reversed these effects. Curcumin treatment ameliorated peripheral blood cells generation, enhanced SIRT3 activity, decreased SOD2 acetylation, inhibited mROS production, and suppressed iron loading-induced autophagy. Conclusions Our results suggest that curcumin exerts a protective effect on bone marrow by reducing mROS-stimulated autophagic cell death in a manner dependent on the SIRT3/SOD2 pathway. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1425-8153 1689-1392 |
| Relation: | https://doaj.org/toc/1425-8153; https://doaj.org/toc/1689-1392 |
| DOI: | 10.1186/s11658-020-00244-7 |
| URL الوصول: | https://doaj.org/article/28c412f7e025470489b85257d6e865c9 |
| رقم الأكسشن: | edsdoj.28c412f7e025470489b85257d6e865c9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14258153 16891392 |
|---|---|
| DOI: | 10.1186/s11658-020-00244-7 |