دورية أكاديمية
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis
| العنوان: | The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
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| المؤلفون: | Nafiu Aminu, Mun-Fei Yam, Siok-Yee Chan, Idris Bello, Nura Muhammad Umar, Tanko Nuhu, Seok-Ming Toh |
| المصدر: | Saudi Dental Journal, Vol 33, Iss 7, Pp 554-559 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Dentistry |
| مصطلحات موضوعية: | Experimental periodontitis, Morphometric analysis, Rat incisors, Nanogels, Triclosan, Flurbiprofen, Medicine, Dentistry, RK1-715 |
| الوصف: | Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis in rats. Methodology: A total of 72 Sprague–Dawley rats were used in this study. Four groups (n = 18 each) were randomly created: Group 1 – neither subjected to experimental periodontitis nor to any treatment; Group 2 – subjected to experimental periodontitis but not treated; Group 3 – subjected to experimental periodontitis and then treated with the developed nanogels; Group 4 – subjected to experimental periodontitis and then placed on a mixture of pure TCS and FLB treatment. The experimental periodontitis was induced on the lower incisors by applying a ligature which was kept for 14 days. Treatment was done for 7 days, and sampling was done at 7, 14, and 28 day of the post-induction experimental period. Morphometric analysis was conducted to assess the clinical outcomes and healing effect. Results: The morphometric findings showed that the group treated with the developed TCS and FLB-loaded nanogels recovered better and faster than a mixture of pure TCS and FLB. At 28 day of the experimental period, there was no significant difference (p > 0.05) between the baseline control group and the nanogels treated group. Conclusions: The developed TCS and FLB-loaded nanogels was found to be effective in the treatment of experimental periodontitis in rats. The used experimental periodontitis model was found to be simple and easily reproducible. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1013-9052 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1013905220307677; https://doaj.org/toc/1013-9052 |
| DOI: | 10.1016/j.sdentj.2020.08.008 |
| URL الوصول: | https://doaj.org/article/28d1dbe3af154cf09db0c4335b7e9769 |
| رقم الأكسشن: | edsdoj.28d1dbe3af154cf09db0c4335b7e9769 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10139052 |
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| DOI: | 10.1016/j.sdentj.2020.08.008 |