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Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents

التفاصيل البيبلوغرافية
العنوان: Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents
المؤلفون: Tam Minh Le, Thu Huynh, Fatima Zahra Bamou, András Szekeres, Ferenc Fülöp, Zsolt Szakonyi
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 11, p 5626 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: (+)-neoisopulegol, O-Benzyl derivatives, imidazole, 1,2,4-triazole, aminodiol, aminotriol, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Discovery of novel antibacterial agents with new structures, which combat pathogens is an urgent task. In this study, a new library of (+)-neoisopulegol-based O-benzyl derivatives of aminodiols and aminotriols was designed and synthesized, and their antimicrobial activity against different bacterial and fungal strains were evaluated. The results showed that this new series of synthetic O-benzyl compounds exhibit potent antimicrobial activity. Di-O-benzyl derivatives showed high activity against Gram-positive bacteria and fungi, but moderate activity against Gram-negative bacteria. Therefore, these compounds may serve a good basis for antibacterial and antifungal drug discovery. Structure–activity relationships were also studied from the aspects of stereochemistry of the O-benzyl group on cyclohexane ring and the substituent effects on the ring system.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/22/11/5626; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms22115626
URL الوصول: https://doaj.org/article/28f5783ec22544c592cab6cc7ca6d839
رقم الأكسشن: edsdoj.28f5783ec22544c592cab6cc7ca6d839
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms22115626