دورية أكاديمية
Blood chromium and lung function among Chinese young adults: A comprehensive analysis based on epidemiology and metabolomics
| العنوان: | Blood chromium and lung function among Chinese young adults: A comprehensive analysis based on epidemiology and metabolomics |
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| المؤلفون: | Mingyu Feng, Lingyan Qiao, Qingxia Yu, Meiling Liu, Jia Zhang, Shuo Wen, Xinyuan Li, Victor Teng, Lailai Yan, Chengshuai Zhang, Shanshan Li, Yuming Guo, Peng Lu |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 281, Iss , Pp 116594- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Blood chromium, Lung function, Metabolomics, Lipidomics, Young adults, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Chromium (Cr) exposure is associated with various respiratory system diseases, but there are limited studies investigating its impact on lung function in young adults. The Cr exposure-related metabolomic changes are not well elucidated. This study recruited 608 students from a university in Shandong Province, China in 2019. We used cohort design fitted with linear mixed-effects models to assess the association between blood Cr concentration and lung function. In addition, we performed metabolomic and lipidomic analyses of baseline serum samples (N = 582) using liquid chromatography-mass spectrometry. Two-step statistical analysis (analysis of variance and mixed-linear effect model) was used to evaluate the effect of blood Cr exposure on metabolites. We found that blood Cr was associated with decreased lung function in young adults. Each 2-fold increase in blood Cr concentrations was significantly associated with decreased FEV1 and FVC by 35.26 mL (95 % CI: −60.75, −9.78) and 38.56 mL (95 % CI: −66.60, −10.51), respectively. In the metabolomics analysis, blood Cr exposure was significantly associated with 14 key metabolites. The changed metabolites were mainly enriched in six pathways including lipid metabolism, amino acid metabolism, and cofactor vitamin metabolism. Blood Cr may affect lung function through oxidative stress and inflammation related pathways. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324006705; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116594 |
| URL الوصول: | https://doaj.org/article/dc2926b72495440ca6132579924e2023 |
| رقم الأكسشن: | edsdoj.2926b72495440ca6132579924e2023 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116594 |