التفاصيل البيبلوغرافية
العنوان:
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis
المؤلفون:
Kosaku Okuda , Kengo Nakahara , Akihiro Ito , Yuta Iijima , Ryosuke Nomura , Ashutosh Kumar , Kana Fujikawa , Kazuya Adachi , Yuki Shimada , Satoshi Fujio , Reina Yamamoto , Nobumasa Takasugi , Kunishige Onuma , Mitsuhiko Osaki , Futoshi Okada , Taichi Ukegawa , Yasuo Takeuchi , Norihisa Yasui , Atsuko Yamashita , Hiroyuki Marusawa , Yosuke Matsushita , Toyomasa Katagiri , Takahiro Shibata , Koji Uchida , Sheng-Yong Niu , Nhi B. Lang , Tomohiro Nakamura , Kam Y. J. Zhang , Stuart A. Lipton , Takashi Uehara
المصدر:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
بيانات النشر:
Nature Portfolio, 2023.
سنة النشر:
2023
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic conversion in vivo.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-023-36232-6
URL الوصول:
https://doaj.org/article/2948479591604774a634757fd4634fae
رقم الأكسشن:
edsdoj.2948479591604774a634757fd4634fae
قاعدة البيانات:
Directory of Open Access Journals
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