دورية أكاديمية
Therapeutic Strategies Against COVID-19 and Structural Characterization of SARS-CoV-2: A Review
| العنوان: | Therapeutic Strategies Against COVID-19 and Structural Characterization of SARS-CoV-2: A Review |
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| المؤلفون: | Gi Uk Jeong, Hanra Song, Gun Young Yoon, Doyoun Kim, Young-Chan Kwon |
| المصدر: | Frontiers in Microbiology, Vol 11 (2020) |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, 2019-nCoV, antiviral agents, therapeutic strategies, crystal structure, Microbiology, QR1-502 |
| الوصف: | The novel coronavirus, SARS-CoV-2, or 2019-nCoV, which originated in Wuhan, Hubei province, China in December 2019, is a grave threat to public health worldwide. A total of 3,672,238 confirmed cases of coronavirus disease 2019 (COVID-19) and 254,045 deaths were reported globally up to May 7, 2020. However, approved antiviral agents for the treatment of patients with COVID-19 remain unavailable. Drug repurposing of approved antivirals against other viruses such as HIV or Ebola virus is one of the most practical strategies to develop effective antiviral agents against SARS-CoV-2. A combination of repurposed drugs can improve the efficacy of treatment, and structure-based drug design can be employed to specifically target SARS-CoV-2. This review discusses therapeutic strategies using promising antiviral agents against SARS-CoV-2. In addition, structural characterization of potentially therapeutic viral or host cellular targets associated with COVID-19 have been discussed to refine structure-based drug design strategies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-302X 52577147 |
| Relation: | https://www.frontiersin.org/article/10.3389/fmicb.2020.01723/full; https://doaj.org/toc/1664-302X |
| DOI: | 10.3389/fmicb.2020.01723 |
| URL الوصول: | https://doaj.org/article/2961da5257714733809eb9951b5d2071 |
| رقم الأكسشن: | edsdoj.2961da5257714733809eb9951b5d2071 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1664302X 52577147 |
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| DOI: | 10.3389/fmicb.2020.01723 |