دورية أكاديمية
Patients with Darier Disease Exhibit Cognitive Impairment while Patients with Hailey-Hailey Disease Do Not: An Experimental, Matched Case-control Study
| العنوان: | Patients with Darier Disease Exhibit Cognitive Impairment while Patients with Hailey-Hailey Disease Do Not: An Experimental, Matched Case-control Study |
|---|---|
| المؤلفون: | Philip Curman, Johanna Bern, Linnea Sand, Martin Cederlöf, Etty Bachar-Wikström, Jakob D. Wikström |
| المصدر: | Acta Dermato-Venereologica, Vol 101, Iss 6, p adv00476 (2021) |
| بيانات النشر: | Medical Journals Sweden, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | darier disease, hailey-hailey disease, cognition, cognitive impairment, serca2, spca1, Dermatology, RL1-803 |
| الوصف: | Darier disease and Hailey-Hailey disease are severe, monogenetic dermatological disorders with mutations affecting all cells, making them liable to exhibit extra-dermal symptoms. The aim of this study is to assess broad cognitive function in individuals with these diseases, using an experimental, case-control set-up comparing cognition in patients with that in healthy controls matched for age, sex and level of education. Cognition was assessed with the Cambridge Neuropsychological Test Automated Battery. Patients with Darier disease (n = 29) performed significantly poorer on 5 of the 10 key cognitive measurements, while patients with Hailey-Hailey disease (n = 25) did not perform differently from controls. The main conclusion is that patients with Darier disease exhibit significant impairment in cognitive function, which reinforces the view that Darier disease should be regarded as a disorder affecting multiple organs, and should therefore be given medical consideration, and possibly treatment, as such. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0001-5555 1651-2057 00015555 |
| Relation: | https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3818; https://doaj.org/toc/0001-5555; https://doaj.org/toc/1651-2057 |
| DOI: | 10.2340/00015555-3818 |
| URL الوصول: | https://doaj.org/article/29791cc0004a40b08ddfbf459c3d069b |
| رقم الأكسشن: | edsdoj.29791cc0004a40b08ddfbf459c3d069b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00015555 16512057 |
|---|---|
| DOI: | 10.2340/00015555-3818 |