دورية أكاديمية
The Gene Polymorphism of LOX1 Predicts the Incidence of LVH in Patients with Essential Hypertension
| العنوان: | The Gene Polymorphism of LOX1 Predicts the Incidence of LVH in Patients with Essential Hypertension |
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| المؤلفون: | Xiaolin Xu, Xuwei Hou, Yixiu Liang, Fan Li, Liewen Pang, Guoqian Huang, Jiechun Huang, Meng Shi, Xiaotian Sun, Yiqing Wang |
| المصدر: | Cellular Physiology and Biochemistry, Vol 33, Iss 1, Pp 88-96 (2014) |
| بيانات النشر: | Cell Physiol Biochem Press GmbH & Co KG, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | Essential hypertension, Left ventricular hypertrophy, SNP, Lectin-like oxidized low-density lipoprotein receptor-1, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been shown to play an important role in cardiac remodeling under different pathologic conditions. The role of genetic polymorphisms in the LOX1 gene, however, remains unclear in the development of left ventricular hypertrophy (LVH) for patients with hypertension. Methods: A total of 536 patients diagnosed with essential hypertension (EH) were recruited in this study. Patients were assigned to the LVH+ (n=143) and LVH- (n=393) groups, respectively. The serum LOX1 level was measured and three single nucleotide polymorphisms (SNPs), i.e. intron 4 (G→A), intron 5(T→G), and 3′ UTR (T→C) of the LOX1 gene were genotyped. Results: The genotype frequencies of intron 4 G>A and 3′UTR T>C were not significantly different between the LVH+ and LVH- groups (both P>0.05), however, frequencies of 501G>C were significantly different between those two groups (P=0.007). The 501CC genotype carriers had a markedly higher serum LOX1 level and an increased risk to develop LVH (adjusted OR=2.444, adjusted P=0.002). There was a positive correlation between serum LOX1 level and left ventricular mass index (r=0.907, PConclusion: Our data suggest that both the 501>C SNP in the LOX1 gene and the serum LOX1 level may be used to predict the development of LVH among EH patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1015-8987 1421-9778 |
| Relation: | http://www.karger.com/Article/FullText/356652; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778 |
| DOI: | 10.1159/000356652 |
| URL الوصول: | https://doaj.org/article/29c87f0ae2f241c6887aa1353b5ee36f |
| رقم الأكسشن: | edsdoj.29c87f0ae2f241c6887aa1353b5ee36f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10158987 14219778 |
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| DOI: | 10.1159/000356652 |