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Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats

التفاصيل البيبلوغرافية
العنوان: Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats
المؤلفون: Yi-Qun Liu, Zheng Jia, Feng Han, Takahiro Inakuma, Tatsuya Miyashita, Kimio Sugiyama, Li-Cui Sun, Xue-Song Xiang, Zhen-Wu Huang
المصدر: The Scientific World Journal, Vol 2014 (2014)
بيانات النشر: Hindawi Limited, 2014.
سنة النشر: 2014
المجموعة: LCC:Technology
LCC:Medicine
LCC:Science
مصطلحات موضوعية: Technology, Medicine, Science
الوصف: Betaine is an important natural component of rich food sources, especially spinach. Rats were fed diets with betaine or spinach powder at the same level of betaine for 10 days to investigate the dose-dependent effects of spinach powder supplementation on hyperhomocysteinemia induced by guanidinoacetic acid (GAA) addition and choline deprivation. The GAA-induced hyperhomocysteinemia in rats fed 25% casein diet (25C) was significantly suppressed by supplementation with betaine or spinach, and it was completely suppressed by taking 11.0% spinach supplementation. The choline deprivation-induced enhancement of plasma homocysteine concentration in rats fed 25% soybean protein diet (25S) was markedly suppressed by 3.82% spinach. Supplementation with betaine or spinach partially prevented the effects of GAA on hepatic concentrations of methionine metabolites. The decrease in activity of betaine-homocysteine S-methyltransferase (BHMT) and cystathionine β-synthase (CBS) in GAA-induced hyperhomocysteinemia was recovered by supplementation with betaine or spinach. Supplementation with betaine or spinach did not affect BHMT activity, whereas it partially restored CBS activity in choline-deprived 25S. The results indicated that betaine or spinach could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2356-6140
1537-744X
Relation: https://doaj.org/toc/2356-6140; https://doaj.org/toc/1537-744X
DOI: 10.1155/2014/904501
URL الوصول: https://doaj.org/article/29d9cf7da4ae4e88b0ecf337d8fdf4c0
رقم الأكسشن: edsdoj.29d9cf7da4ae4e88b0ecf337d8fdf4c0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23566140
1537744X
DOI:10.1155/2014/904501