دورية أكاديمية
Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse
| العنوان: | Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse |
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| المؤلفون: | Vanessa Troiani, Richard C. Crist, Glenn A. Doyle, Thomas N. Ferraro, Donielle Beiler, Stephanie Ranck, Kortney McBryan, Margaret A. Jarvis, Jordan S. Barbour, John J. Han, Ryan J. Ness, Wade H. Berrettini, Janet D. Robishaw |
| المصدر: | BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Opioid use disorder (OUD), Genetics, Addiction, Substance misuse, Internal medicine, RC31-1245, QH426-470 |
| الوصف: | Abstract Background Prescription opioids (POs) are commonly used to treat moderate to severe chronic pain in the health system setting. Although they improve quality of life for many patients, more work is needed to identify both the clinical and genetic factors that put certain individuals at high risk for developing opioid use disorder (OUD) following use of POs for pain relief. With a greater understanding of important risk factors, physicians will be better able to identify patients at highest risk for developing OUD for whom non-opioid alternative therapies and treatments should be considered. Methods We are conducting a prospective observational study that aims to identify the clinical and genetic factors most stongly associated with OUD. The study design leverages an existing biobank that includes whole exome sequencing and array genotyping. The biobank is maintained within an integrated health system, allowing for the large-scale capture and integration of genetic and non-genetic data. Participants are enrolled into the health system biobank via informed consent and then into a second study that focuses on opioid medication use. Data capture includes validated self-report surveys measuring addiction severity, depression, anxiety, and nicotine use, as well as additional clinical, prescription, and brain imaging data extracted from electronic health records. Discussion We will harness this multimodal data capture to establish meaningful patient phenotypes in order to understand the genetic and non-genetic contributions to OUD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1755-8794 |
| Relation: | https://doaj.org/toc/1755-8794 |
| DOI: | 10.1186/s12920-021-01100-z |
| URL الوصول: | https://doaj.org/article/aa29f8a7780448eb9cd5ffe46d15af0e |
| رقم الأكسشن: | edsdoj.29f8a7780448eb9cd5ffe46d15af0e |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17558794 |
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| DOI: | 10.1186/s12920-021-01100-z |