دورية أكاديمية
Artificial Tumor Microenvironments in Neuroblastoma
| العنوان: | Artificial Tumor Microenvironments in Neuroblastoma |
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| المؤلفون: | Colin H. Quinn, Andee M. Beierle, Elizabeth A. Beierle |
| المصدر: | Cancers, Vol 13, Iss 7, p 1629 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | neuroblastoma, tumor microenvironment, three-dimensional bioprinting, three-dimensional modeling, cancer associated fibroblasts, mesenchymal stromal cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | In the quest to advance neuroblastoma therapeutics, there is a need to have a deeper understanding of the tumor microenvironment (TME). From extracellular matrix proteins to tumor associated macrophages, the TME is a robust and diverse network functioning in symbiosis with the solid tumor. Herein, we review the major components of the TME including the extracellular matrix, cytokines, immune cells, and vasculature that support a more aggressive neuroblastoma phenotype and encumber current therapeutic interventions. Contemporary treatments for neuroblastoma are the result of traditional two-dimensional culture studies and in vivo models that have been translated to clinical trials. These pre-clinical studies are costly, time consuming, and neglect the study of cofounding factors such as the contributions of the TME. Three-dimensional (3D) bioprinting has become a novel approach to studying adult cancers and is just now incorporating portions of the TME and advancing to study pediatric solid. We review the methods of 3D bioprinting, how researchers have included TME pieces into the prints, and highlight present studies using neuroblastoma. Ultimately, incorporating the elements of the TME that affect neuroblastoma responses to therapy will improve the development of innovative and novel treatments. The use of 3D bioprinting to achieve this aim will prove useful in developing optimal therapies for children with neuroblastoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13071629 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/13/7/1629; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers13071629 |
| URL الوصول: | https://doaj.org/article/2a4c9ee42c30462aa6c36b09a03e905a |
| رقم الأكسشن: | edsdoj.2a4c9ee42c30462aa6c36b09a03e905a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13071629 20726694 |
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| DOI: | 10.3390/cancers13071629 |