دورية أكاديمية
Haemodynamic, hormonal and renal actions of osteocrin in normal sheep
| العنوان: | Haemodynamic, hormonal and renal actions of osteocrin in normal sheep |
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| المؤلفون: | Nicola J. A. Scott, Timothy C. R. Prickett, Christopher J. Charles, Eric A. Espiner, A. Mark Richards, Miriam T. Rademaker |
| المصدر: | Experimental Physiology, Vol 109, Iss 8, Pp 1305-1316 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Physiology |
| مصطلحات موضوعية: | cAMP, cGMP, natriuretic peptides, osteocrin metabolism, osteocrin molecular forms, Physiology, QP1-981 |
| الوصف: | Abstract Osteocrin (OSTN) is an endogenous protein sharing structural similarities with the natriuretic peptides [NPs; atrial (ANP), B‐type (BNP) and C‐type (CNP) NP], which are hormones known for their crucial role in maintaining pressure/volume homeostasis. Osteocrin competes with the NPs for binding to the receptor involved in their clearance (NPR‐C). In the present study, having identified, for the first time, the major circulating form of OSTN in human and ovine plasma, we examined the integrated haemodynamic, endocrine and renal effects of vehicle‐controlled incremental infusions of ovine proOSTN (83–133) and its metabolism in eight conscious normal sheep. Incremental i.v. doses of OSTN produced stepwise increases in circulating concentrations of the peptide, and its metabolic clearance rate was inversely proportional to the dose. Osteocrin increased plasma levels of ANP, BNP and CNP in a dose‐dependent manner, together with concentrations of their intracellular second messenger, cGMP. Increases in plasma cGMP were associated with progressive reductions in arterial pressure and central venous pressure. Plasma cAMP, renin and aldosterone were unchanged. Despite significant increases in urinary cGMP levels, OSTN administration was not associated with natriuresis or diuresis in normal sheep. These results support OSTN as an endogenous ligand for NPR‐C in regulating plasma concentrations of NPs and associated cGMP‐mediated bioactivity. Collectively, our findings support a role for OSTN in maintaining cardiovascular homeostasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1469-445X 0958-0670 09578943 |
| Relation: | https://doaj.org/toc/0958-0670; https://doaj.org/toc/1469-445X |
| DOI: | 10.1113/EP091826 |
| URL الوصول: | https://doaj.org/article/2a7d5c0957894317900789ec13b024b4 |
| رقم الأكسشن: | edsdoj.2a7d5c0957894317900789ec13b024b4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1469445X 09580670 09578943 |
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| DOI: | 10.1113/EP091826 |