دورية أكاديمية
أعرض في EDS

Protective Effects of Imatinib and Ginkgo Biloba on Cisplatin-induced Ovarian Damage in Rats

التفاصيل البيبلوغرافية
العنوان: Protective Effects of Imatinib and Ginkgo Biloba on Cisplatin-induced Ovarian Damage in Rats
المؤلفون: Önder Sakin, Ali Doğukan Anğın, Kazibe Koyuncu, Muzaffer Seyhan Çıkman, Kayhan Başak, Asuman Orçun Kaptanağası
المصدر: İstanbul Medical Journal, Vol 21, Iss 4, Pp 281-289 (2020)
بيانات النشر: Galenos Yayinevi, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
مصطلحات موضوعية: cisplatin, imatinib, ginkgo biloba, anti-mullerian hormone, ovary, rat, Medicine
الوصف: Introduction:In our study we aimed to observe the protective effects of imatinib and ginkgo biloba (GB) on cisplatin (CP)- induced ovarian damage in rats.Methods:Thirty-two female rats were included and assigned to four groups. Group 1 had no medication. Their ovaries were removed for examination and the serum Anti-Mullerian hormone (AMH) levels were measured. Group 2 received a single dose of 7.5 mg/kg intramuscular CP. Group 3 received a single dose of 7.5 mg/kg oral imatinib and 30 minutes later, a single dose of 7.5 mg/kg intramuscular CP was administered. Group 4 received 80 mg/kg oral GB for 10 days. Sixty minutes after the first administration of the GB, a single dose of 7.5 mg/kg intramuscular CP was administered. The ovaries and serum AMH levels of the rats were assessed after 10 days of observation.Results:Comparing group 1 and 2 showed that the total histopathological ovarian damage scores increased in the latter (p=0.044). This group also had decreased primordial follicles, preantral follicles and serum AMH (p=0.001, p=0.004 and p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2619-9793
2148-094X
Relation: http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/protective-effects-of-matinib-and-ginkgo-biloba-on/39833; https://doaj.org/toc/2619-9793; https://doaj.org/toc/2148-094X
DOI: 10.4274/imj.galenos.2020.46667
URL الوصول: https://doaj.org/article/a2a92bf417554773a8bbe349dcad0c2d
رقم الأكسشن: edsdoj.2a92bf417554773a8bbe349dcad0c2d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26199793
2148094X
DOI:10.4274/imj.galenos.2020.46667