دورية أكاديمية
Anti-tumor necrosis factor-α is potentially better than tumor necrosis factor-α as the biomarker for sarcopenia: Results from the I-Lan longitudinal aging study
| العنوان: | Anti-tumor necrosis factor-α is potentially better than tumor necrosis factor-α as the biomarker for sarcopenia: Results from the I-Lan longitudinal aging study |
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| المؤلفون: | Wei-Ju Lin, Wei-Ju Lee, Li-Ning Peng, Yi-Long Huang, Chien-Yi Tung, Chi-Hung Lin, Ting-Fen Tsai, Liang-Kung Chen |
| المصدر: | Experimental Gerontology, Vol 172, Iss , Pp 112053- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | TNF-α, Anti-TNF-α, Sarcopenia, Community-dwelling older adults, Biomarker, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natural consequent autoantibody to TNF-α, is an indicator of relatively prolonged TNF-α exposure, has more stable concentrations than TNF-α and should be a better alternative as a biomarker of sarcopenia. Data from 484 participants from the I-Lan Longitudinal Aging Study were used for this study, and sarcopenia was defined by the Asian Working Group for Sarcopenia 2019 consensus. Plasma levels of anti-TNF-α were determined by a sandwich ELISA approach, and levels of TNF-α were determined by an immunoassay. Compared to nonsarcopenic participants, 43 sarcopenic participants had higher levels of anti-TNF-α (0.73 ± 0.19 vs. 0.79 ± 0.25 OD, p = 0.045). Plasma levels of anti-TNF-α were positively correlated with TNF-α (r = 0.24, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1873-6815 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S053155652200362X; https://doaj.org/toc/1873-6815 |
| DOI: | 10.1016/j.exger.2022.112053 |
| URL الوصول: | https://doaj.org/article/2a9e3e03109147ba8a8d80655a53bc6d |
| رقم الأكسشن: | edsdoj.2a9e3e03109147ba8a8d80655a53bc6d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18736815 |
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| DOI: | 10.1016/j.exger.2022.112053 |