دورية أكاديمية
أعرض في EDS

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

التفاصيل البيبلوغرافية
العنوان: Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
المؤلفون: Fangzhu Zhao, Zachary T. Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D. Allen, Shawn Barman, Wen-Hsin Lee, Srirupa Chakraborty, Sandrasegaram Gnanakaran, Leigh M. Sewall, Gabriel Ozorowski, Oliver Limbo, Ge Song, Peter Yong, Sean Callaghan, Jessica Coppola, Kim L. Weisgrau, Jeffrey D. Lifson, Rebecca Nedellec, Thomas B. Voigt, Fernanda Laurino, Johan Louw, Brandon C. Rosen, Michael Ricciardi, Max Crispin, Ronald C. Desrosiers, Eva G. Rakasz, David I. Watkins, Raiees Andrabi, Andrew B. Ward, Dennis R. Burton, Devin Sok
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in passive transfer studies in macaques. The nAb was used to provide the first high-resolution structure of a rhesus SIV trimer by CryoEM. Analysis of the glycosylation pattern of this SIV trimer suggests a denser glycan shield on Env for rhesus SIV compared to chimpanzee SIV or HIV-1, which partially explains the poor nAb response of rhesus macaques to SIVmac239 infection.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-32783-2
URL الوصول: https://doaj.org/article/2aa7798e6f944e178232a7a70fe98e0c
رقم الأكسشن: edsdoj.2aa7798e6f944e178232a7a70fe98e0c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-022-32783-2