دورية أكاديمية
Silica 3D printed scaffolds as pH stimuli-responsive drug release platform
| العنوان: | Silica 3D printed scaffolds as pH stimuli-responsive drug release platform |
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| المؤلفون: | Raquel Rodríguez-González, José Ángel Delgado, Luis M. Delgado, Román A. Pérez |
| المصدر: | Materials Today Bio, Vol 28, Iss , Pp 101187- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Silica sol-gel, 3D printing, Bioactivity, pH-sensitive, Stimuli-responsive, Drug delivery systems, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Silica-based scaffolds are promising in Tissue Engineering by enabling personalized scaffolds, boosting exceptional bioactivity and osteogenic characteristics. Moreover, silica materials are highly tunable, allowing for controlled drug release to enhance tissue regeneration. In this study, we developed a 3D printable silica material with controlled mesoporosity, achieved through the sol-gel reaction of tetraethyl orthosilicate (TEOS) at mild temperatures with the addition of different calcium concentrations. The resultant silica inks exhibited high printability and shape fidelity, while maintaining bioactivity and biocompatibility. Notably, the increased mesopore size enhanced the incorporation and release of large molecules, using cytochrome C as a drug model. Due to the varying surface charge of silica depending on the pH, a pH-dependent control release was obtained between pH 2.5 and 7.5, with maximum release in acidic conditions. Therefore, silica with controlled mesoporosity could be 3D printed, acting as a pH stimuli responsive platform with therapeutic potential. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006424002485; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2024.101187 |
| URL الوصول: | https://doaj.org/article/2b20c6962237416ca66ca704dd61f363 |
| رقم الأكسشن: | edsdoj.2b20c6962237416ca66ca704dd61f363 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2024.101187 |