دورية أكاديمية
Prevalence of bla VIM , bla IMP , and bla KPC Genes Among Carbapenem-Resistant Klebsiella pneumoniae (CRKP) Isolated from Kurdistan and Isfahan Hospitals, Iran
| العنوان: | Prevalence of bla VIM , bla IMP , and bla KPC Genes Among Carbapenem-Resistant Klebsiella pneumoniae (CRKP) Isolated from Kurdistan and Isfahan Hospitals, Iran |
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| المؤلفون: | Leila gheitani, Hossein Fazeli |
| المصدر: | Research in Molecular Medicine, Vol 2017, Pp 1-9 (2018) |
| بيانات النشر: | Mazandaran University of Medical Sciences and Health Services, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | bla VIM , bla IMP , bla KPC , Carbapenemase, Klebsiella pneumoniae, Medicine (General), R5-920 |
| الوصف: | Background: Carbapenem resistance among Klebsiella pneumoniae is an emerging problem worldwide. One of the main mechanisms of resistance to carbapenems is the potential of Klebsiella pneumoniae to produce carbapenemase enzyme.This study was conducted to determine the frequency of bla VIM, bla IMP, and bla KPC among carbapenem-resistant K. pneumoniae (CRKP) isolated from Kurdistan and Isfahan hospitals.Materials and Methods: This study was carried out in Iran using 183 samples from the Besat and Alzahra hospitals in 2017. Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion. The modified Hodge test (MHT) was used to investigate the presence of carbapenemase. The β-lactamases genes were detected by PCR.Results: The highest and lowest rates of resistance were observed against cefotaxime (98.2%) and gentamicin (43.6%), respectively. Among the 183 isolates, 134 (73.2 %) were positive by the MHT. The prevalence rates of bla VIM, bla IMP, and bla KPC were 4 (2.18%), 1 (0.5%), and 0%, respectively.Conclusion: The prevalence of CRKP strains is a major concern and infection control processes are needed. These gene showed a low prevalence in our country, likely because other mechanisms of resistance to carbapenems are involved. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2322-1348 93394381 |
| Relation: | https://doaj.org/toc/2322-1348 |
| DOI: | 10.18502/rmm.v6i2.4536 |
| URL الوصول: | https://doaj.org/article/a2b39d74180d441c933943813136c698 |
| رقم الأكسشن: | edsdoj.2b39d74180d441c933943813136c698 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23221348 93394381 |
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| DOI: | 10.18502/rmm.v6i2.4536 |