دورية أكاديمية
Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner
| العنوان: | Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner |
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| المؤلفون: | Towako Hiraki-Kajiyama, Junpei Yamashita, Keiko Yokoyama, Yukiko Kikuchi, Mikoto Nakajo, Daichi Miyazoe, Yuji Nishiike, Kaito Ishikawa, Kohei Hosono, Yukika Kawabata-Sakata, Satoshi Ansai, Masato Kinoshita, Yoshitaka Nagahama, Kataaki Okubo |
| المصدر: | eLife, Vol 8 (2019) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | neuropeptide B, sexual dimorphism, sexual lability, sex steroid, mating behavior, female receptivity, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/39495; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.39495 |
| URL الوصول: | https://doaj.org/article/2b485118ac6a42cea38c7b7e32a074bc |
| رقم الأكسشن: | edsdoj.2b485118ac6a42cea38c7b7e32a074bc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.39495 |