دورية أكاديمية
Methylation of the Vitamin D Receptor Gene in Human Disorders
| العنوان: | Methylation of the Vitamin D Receptor Gene in Human Disorders |
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| المؤلفون: | Beatrice Gasperini, Angela Falvino, Eleonora Piccirilli, Umberto Tarantino, Annalisa Botta, Virginia Veronica Visconti |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 1, p 107 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | vitamin D receptor (VDR), epigenetics, DNA methylation, VDR-related diseases, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 25010107 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/1/107; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25010107 |
| URL الوصول: | https://doaj.org/article/2b58d2d483204b45a4e611ec19f5b6a7 |
| رقم الأكسشن: | edsdoj.2b58d2d483204b45a4e611ec19f5b6a7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25010107 14220067 16616596 |
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| DOI: | 10.3390/ijms25010107 |