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Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors

التفاصيل البيبلوغرافية
العنوان: Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors
المؤلفون: Feng Zeng, Mengxiang Gao, Shan Liao, Zihua Zhou, Gengqiu Luo, Yanhong Zhou
المصدر: Molecular Medicine, Vol 29, Iss 1, Pp 1-13 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Therapeutics. Pharmacology
LCC:Biochemistry
مصطلحات موضوعية: CD90, Fibroblasts, Inflammation, Fibrosis, Pathophysiology, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436
الوصف: Abstract Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different roles. A subpopulation of fibroblasts expressing CD90, a 25–37 kDa glycosylphosphatidylinositol anchored protein, plays a dominant role in the fibrotic and pro-inflammatory state. In this review, we focused on CD90+ fibroblasts, and their roles and possible mechanisms in disease processes. First, the main biological functions of CD90+ fibroblasts in inducing angiogenesis and maintaining tissue homeostasis are described. Second, the role and possible mechanism of CD90+ fibroblasts in inducing pulmonary fibrosis, inflammatory arthritis, inflammatory skin diseases, and scar formation are introduced, and we discuss how CD90+ cancer-associated fibroblasts might serve as promising cancer biomarkers. Finally, we propose future research directions related to CD90+ fibroblasts. This review will provide a theoretical basis for the diagnosis and treatment CD90+ fibroblast-related disease.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1528-3658
Relation: https://doaj.org/toc/1528-3658
DOI: 10.1186/s10020-023-00616-7
URL الوصول: https://doaj.org/article/2b6717ea8fee4829893639974903282f
رقم الأكسشن: edsdoj.2b6717ea8fee4829893639974903282f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15283658
DOI:10.1186/s10020-023-00616-7