دورية أكاديمية
The role of the NLRP3 inflammasome in pulmonary diseases
| العنوان: | The role of the NLRP3 inflammasome in pulmonary diseases |
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| المؤلفون: | Nima Hosseinian, Young Cho, Richard F. Lockey, Narasaiah Kolliputi |
| المصدر: | Therapeutic Advances in Respiratory Disease, Vol 9 (2015) |
| بيانات النشر: | SAGE Publishing, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Diseases of the respiratory system, RC705-779 |
| الوصف: | Respiratory diseases and lung injuries are one of the leading causes of death in the world. One critical component of these diseases is exaggerated inflammatory response. The recently discovered inflammasome is believed to play a key role in inflammation. The inflammasome is an oligomer of intracellular proteins that, once activated by an insult or damage signal, produces mature cytokines from the interleukin-1 family that mediate an inflammatory response. Previous research has provided evidence that suggests the role of the inflammasome in the pathogenesis of many chronic respiratory diseases and acute lung injuries, such as transfusion-related acute lung injury, ventilator-induced lung injury, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. This article summarizes recent research on the inflammasome and reviews proposed molecular models of the role of the inflammasome in several prominent lung diseases and injuries. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-4658 1753-4666 17534658 |
| Relation: | https://doaj.org/toc/1753-4658; https://doaj.org/toc/1753-4666 |
| DOI: | 10.1177/1753465815586335 |
| URL الوصول: | https://doaj.org/article/c2b99b7ef5914eb68b3c7efa31ca769d |
| رقم الأكسشن: | edsdoj.2b99b7ef5914eb68b3c7efa31ca769d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17534658 17534666 |
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| DOI: | 10.1177/1753465815586335 |