دورية أكاديمية
Lipase Immobilized on MCFs as Biocatalysts for Kinetic and Dynamic Kinetic Resolution of sec-Alcohols
| العنوان: | Lipase Immobilized on MCFs as Biocatalysts for Kinetic and Dynamic Kinetic Resolution of sec-Alcohols |
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| المؤلفون: | Dominika Stradomska, Monika Heba, Aleksandra Czernek, Nikodem Kuźnik, Danuta Gillner, Katarzyna Maresz, Wojciech Pudło, Andrzej Jarzębski, Katarzyna Szymańska |
| المصدر: | Catalysts, Vol 11, Iss 4, p 518 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Chemical technology LCC:Chemistry |
| مصطلحات موضوعية: | chiral secondary alcohols, resolution of enantiomers, dynamic kinetic resolution, DKR, synthesis of enantiomers, bicatalytic tandem, Chemical technology, TP1-1185, Chemistry, QD1-999 |
| الوصف: | Dynamic kinetic resolution (DKR) is one of the most attractive methods for enantioselective synthesis. In the reported studies, lipase B from Candida antarctica (CALB) immobilized on siliceous mesoporous cellular foams (MCF) functionalized with different hydrophobic groups, and two ruthenium complexes with substituted cyclopentadienyl ligands were investigated as catalysts for the chemoenzymatic DKR of (rac)-1-phenylethanol, using Novozym 435 as a benchmark biocatalyst. Studies on the (rac)-1-phenylethanol transesterification reaction showed that CALB supported on MCFs grafted with methyl groups is a promising biocatalyst and isopropenyl acetate is a preferable acylation agent. Both Ru-complexes activated by K3PO4 or t-BuOK, proved to be effective catalysts of the racemization reaction. The final DKR experiments using all catalysts combinations singled out, gave 96% conversion, and (R)-1-phenylethyl acetate enantiomeric excess of 98% in 8 h using K3PO4 activator. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2073-4344 |
| Relation: | https://www.mdpi.com/2073-4344/11/4/518; https://doaj.org/toc/2073-4344 |
| DOI: | 10.3390/catal11040518 |
| URL الوصول: | https://doaj.org/article/2b9b5b1d53a441bda16d0668d5a308fc |
| رقم الأكسشن: | edsdoj.2b9b5b1d53a441bda16d0668d5a308fc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20734344 |
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| DOI: | 10.3390/catal11040518 |