دورية أكاديمية
Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal
| العنوان: | Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal |
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| المؤلفون: | Marta Aires-de-Sousa, José Manuel Ortiz de la Rosa, Maria Luísa Gonçalves, Ana Luísa Pereira, Patrice Nordmann, Laurent Poirel |
| المصدر: | Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1632-1638 (2019) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | carbapenemase, Klebsiella pneumoniae, Portugal, KPC-3, OXA-181, GES-5, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013–2018 in a 123-bed hospital in Lisbon. We identified blaKPC-3 (n = 36), blaOXA-181 (n = 9), and blaGES-5 (n = 8) carbapenemase genes and observed co-occurrence of blaKPC-3 and blaGES-5 in 7 isolates. A single GES-5–producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co-located on the same ColE1-like plasmid. The blaOXA-181 gene was always located on an IncX3 plasmid, whereas blaKPC-3 was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/25/9/19-0656_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2509.190656 |
| URL الوصول: | https://doaj.org/article/ed2bbdcc51a4491892fe33c3ef1685e2 |
| رقم الأكسشن: | edsdoj.2bbdcc51a4491892fe33c3ef1685e2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2509.190656 |