دورية أكاديمية

Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

التفاصيل البيبلوغرافية
العنوان: Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy
المؤلفون: L. Faillace, S. Barone, G. Battistoni, M. Di Francesco, G. Felici, L. Ficcadenti, G. Franciosini, F. Galante, L. Giuliano, L. Grasso, A. Mostacci, S. Muraro, M. Pacitti, L. Palumbo, V. Patera, M. Migliorati
المصدر: Physical Review Accelerators and Beams, Vol 24, Iss 5, p 050102 (2021)
بيانات النشر: American Physical Society, 2021.
سنة النشر: 2021
المجموعة: LCC:Nuclear and particle physics. Atomic energy. Radioactivity
مصطلحات موضوعية: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
الوصف: Radiation therapy is currently the most utilized technique for the treatment of tumors by means of ionizing radiation, such as electrons, protons and x/gamma rays, depending on the type, size and depth of the cancer mass. Radiation therapy has in general fulfilled the main requirement of targeting thus damaging the malignant cells and sparing the healthy tissues as best as possible. In this scenario, electron linear accelerators have been operated as viable tools for the delivery of both high-energetic electrons and x-ray beams, which are obtained via the bremsstrahlung process of the electrons hitting on a high-Z material. Recently, it has been experimentally demonstrated that ultrahigh dose-rate bursts of electrons and x-ray beams increase the differential response between healthy and tumor tissues. This beneficial response is referred to as the FLASH effect. For this purpose, we have developed the first dedicated compact S-band linear accelerator for FLASH radiotherapy. This linac is optimized for a nominal energy of 7 MeV and a pulsed electron beam current of 100 mA and above. The accelerator is mounted on a remote-controlled system for preclinical research studies in the FLASH regime. We will show the rf and beam dynamics design of the S-band linac as well as the commissioning and high-power rf tests. Furthermore, the results of the dosimetric measurements will be illustrated.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2469-9888
Relation: https://doaj.org/toc/2469-9888
DOI: 10.1103/PhysRevAccelBeams.24.050102
URL الوصول: https://doaj.org/article/2bde4205e021480fa49d431bd158e2ba
رقم الأكسشن: edsdoj.2bde4205e021480fa49d431bd158e2ba
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24699888
DOI:10.1103/PhysRevAccelBeams.24.050102