دورية أكاديمية
Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru
| العنوان: | Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru |
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| المؤلفون: | Maria L. Morales, Melinda B. Tanabe, A. Clinton White, Martha Lopez, Ruben Bascope, Miguel M. Cabada |
| المصدر: | Emerging Infectious Diseases, Vol 27, Iss 7, Pp 1850-1857 (2021) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | triclabendazole, treatment failure, fascioliasis, Fasciola hepatica, liver fluke, trematode, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1–4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/27/7/20-3900_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2707.203900 |
| URL الوصول: | https://doaj.org/article/c2befb7139c6493b875973951e187f2e |
| رقم الأكسشن: | edsdoj.2befb7139c6493b875973951e187f2e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2707.203900 |