BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

التفاصيل البيبلوغرافية
العنوان:	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
المؤلفون:	Sen Zhu, Dongyu Zhao, Lin Yan, Weihua Jiang, Jung-Sun Kim, Bingnan Gu, Qipeng Liu, Rui Wang, Bo Xia, Jonathan C. Zhao, Gang Song, Wenyi Mi, Rong-Fu Wang, Xiaobing Shi, Hung-Ming Lam, Xuesen Dong, Jindan Yu, Kaifu Chen, Qi Cao
المصدر:	Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
بيانات النشر:	Nature Portfolio, 2018.
سنة النشر:	2018
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-018-02863-3
URL الوصول:	https://doaj.org/article/2c11102c772b403f8c968a42953aed26
رقم الأكسشن:	edsdoj.2c11102c772b403f8c968a42953aed26
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-018-02863-3