دورية أكاديمية
The role of statins in patients with early diabetic nephropathy
| العنوان: | The role of statins in patients with early diabetic nephropathy |
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| المؤلفون: | Xi Zhao, MM, ID, Shu Chun Zhou, BM, AP, Xiu Fang Wang, MSC, Hong Wu Liao, MM, AP |
| المصدر: | Medicine, Vol 101, Iss 24, p e29099 (2022) |
| بيانات النشر: | Wolters Kluwer, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Abstract. Background:. Little is known about the renoprotective effects of statins on the regulation of urinary oxidative stress markers and proteinuria in patients with diabetic nephropathy. Therefore, we conducted this protocol of systematic review and meta-analysis to evaluate the role of statins in patients with early diabetic nephropathy. Methods:. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols reporting guidelines to conduct this study. The electronic databases EMBASE, PUBMED, CINAHL, and Web of Science will be searched from the earliest available time to July 2022. The population is defined as participants with early diabetic nephropathy. The Intervention groups are given any one of the statins, such as simvastatin or rosuvastatin. The control groups are treated with angiotensin-converting enzyme inhibitor or placebo alone. The primary outcome is estimated glomerular filtration rate; secondary outcome is serological indicators including triglyceride, cholesterol, C-reactive protein, and complications. The Jadad scale will be used to assess the methodological quality of each study included in this meta-analysis. Result & Conclusion:. We hypothesized that statins would have a positive renoprotective effect in such patients. OSF registration number:. 10.17605/OSF.IO/ESMWR. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0025-7974 1536-5964 00000000 |
| Relation: | http://journals.lww.com/10.1097/MD.0000000000029099; https://doaj.org/toc/0025-7974; https://doaj.org/toc/1536-5964 |
| DOI: | 10.1097/MD.0000000000029099 |
| URL الوصول: | https://doaj.org/article/ee2c329f967046bcaa19945b9f7071d4 |
| رقم الأكسشن: | edsdoj.2c329f967046bcaa19945b9f7071d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00257974 15365964 00000000 |
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| DOI: | 10.1097/MD.0000000000029099 |