دورية أكاديمية
Poliovirus Excretion in Children with Primary Immunodeficiency Disorders, India
| العنوان: | Poliovirus Excretion in Children with Primary Immunodeficiency Disorders, India |
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| المؤلفون: | Madhu Chhanda Mohanty, Manisha Rajan Madkaikar, Mukesh Desai, Prasad Taur, Uma Prajwal Nalavade, Deepa Kailash Sharma, Maya Gupta, Aparna Dalvi, Snehal Shabrish, Manasi Kulkarni, Jahnavi Aluri, Jagadish Mohanrao Deshpande |
| المصدر: | Emerging Infectious Diseases, Vol 23, Iss 10, Pp 1664-1670 (2017) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | enterovirus, poliovirus, primary immunodeficiency disorder, oral polio vaccine, OPV, vaccine-derived polioviruses, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Prolonged excretion of poliovirus can occur in immunodeficient patients who receive oral polio vaccine, which may lead to propagation of highly divergent vaccine-derived polioviruses (VDPVs), posing a concern for global polio eradication. This study aimed to estimate the proportion of primary immunodeficient children with enterovirus infection and to identify the long-term polio/nonpolio enterovirus excreters in a tertiary care unit in Mumbai, India. During September 2014–April 2017, 151 patients received diagnoses of primary immunodeficiency (PID). We isolated 8 enteroviruses (3 polioviruses and 5 nonpolio enteroviruses) in cell culture of 105 fecal samples collected from 42 patients. Only 1 patient with severe combined immunodeficiency was identified as a long-term VDPV3 excreter (for 2 years after identification of infection). Our results show that the risk of enterovirus excretion among children in India with PID is low; however, systematic screening is necessary to identify long-term poliovirus excreters until the use of oral polio vaccine is stopped. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/23/10/17-0724_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2310.170724 |
| URL الوصول: | https://doaj.org/article/2c386d6de048452ea7663b42b75d8fb6 |
| رقم الأكسشن: | edsdoj.2c386d6de048452ea7663b42b75d8fb6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2310.170724 |