دورية أكاديمية
MiRNA-based 'fitness score' to assess the individual response to diet, metabolism, and exercise
| العنوان: | MiRNA-based 'fitness score' to assess the individual response to diet, metabolism, and exercise |
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| المؤلفون: | Ulrike D.B. Krammer, Sylvia Tschida, Julia Berner, Stephanie Lilja, Olivier J. Switzeny, Berit Hippe, Petra Rust, Alexander G. Haslberger |
| المصدر: | Journal of the International Society of Sports Nutrition, Vol 19, Iss 1, Pp 455-473 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Sports medicine |
| مصطلحات موضوعية: | exercise, epigenetic, mirnas, biomarker, fitness score, nutrition, Nutrition. Foods and food supply, TX341-641, Sports medicine, RC1200-1245 |
| الوصف: | Background Regular, especially sustained exercise plays an important role in the prevention and treatment of multiple chronic diseases. Some of the underlying molecular and cellular mechanisms behind the adaptive response to physical activity are still unclear, but recent findings suggest a possible role of epigenetic mechanisms, especially miRNAs, in the progression and management of exercise-related changes. Due to the combination of the analysis of epigenetic biomarkers (miRNAs), the intake of food and supplements, and genetic dispositions, a “fitness score” was evaluated to assess the individual response to nutrition, exercise, and metabolic influence. Methods In response to a 12-week sports intervention, we analyzed genetic and epigenetic biomarkers in capillary blood from 61 sedentary, healthy participants (66.1% females, 33.9% males, mean age 33 years), including Line-1 methylation, three SNPs, and ten miRNAs using HRM and qPCR analysis. These biomarkers were also analyzed in a healthy, age- and sex-matched control group (n, 20) without intervention. Food frequency intake, including dietary supplement intake, and general health questionnaires were surveyed under the supervision of trained staff. Results Exercise training decreased the expression of miR-20a-5p, −22-5p, and −505-3p (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1550-2783 15502783 |
| Relation: | https://doaj.org/toc/1550-2783 |
| DOI: | 10.1080/15502783.2022.2106148 |
| URL الوصول: | https://doaj.org/article/cdd2c5885cf7489bb59ae5e235fd5c6a |
| رقم الأكسشن: | edsdoj.2c5885cf7489bb59ae5e235fd5c6a |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 15502783 |
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| DOI: | 10.1080/15502783.2022.2106148 |