دورية أكاديمية
Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease
| العنوان: | Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease |
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| المؤلفون: | Yasufumi Masaki, Nozomu Kurose, Motohisa Yamamoto, Hiroki Takahashi, Takako Saeki, Atsushi Azumi, Shinji Nakada, Shoko Matsui, Tomoki Origuchi, Susumu Nishiyama, Kazunori Yamada, Mitsuhiro Kawano, Akira Hirabayashi, Keita Fujikawa, Tomoko Sugiura, Masanobu Horikoshi, Naoto Umeda, Hiroshi Minato, Takuji Nakamura, Haruka Iwao, Akio Nakajima, Miyuki Miki, Tomoyuki Sakai, Toshioki Sawaki, Takafumi Kawanami, Yoshimasa Fujita, Masao Tanaka, Toshihiro Fukushima, Katumi Eguchi, Susumu Sugai, Hisanori Umehara |
| المصدر: | International Journal of Rheumatology, Vol 2012 (2012) |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | IgG4-related disease is a new disease classification established in Japan in the 21st century. Patients with IgG4-related disease display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids. Since IgG4 overexpression is also observed in other disorders, it is necessary to diagnose IgG4-related disease carefully and correctly. We therefore sought to determine cutoff values for serum IgG4 and IgG4/IgG and for IgG4+/IgG+ plasma cells in tissue diagnostic of IgG4-related disease. Patients and Methods. We retrospectively analyzed serum IgG4 concentrations and IgG4/IgG ratio and IgG4+/IgG+ plasma cell ratio in tissues of 132 patients with IgG4-related disease and 48 patients with other disorders. Result. Serum IgG4 >135 mg/dl demonstrated a sensitivity of 97.0% and a specificity of 79.6% in diagnosing IgG4-related disease, and serum IgG4/IgG ratios >8% had a sensitivity and specificity of 95.5% and 87.5%, respectively. IgG4+cell/IgG+ cell ratio in tissues >40% had a sensitivity and specificity of 94.4% and 85.7%, respectively. However, the number of IgG4+ cells was reduced in severely fibrotic parts of tissues. Conclusion. Although a recent unanimous consensus of all relevant researchers in Japan recently established the diagnostic criteria for IgG4-related disease, findings such as ours indicate that further discussion is needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-9260 1687-9279 |
| Relation: | https://doaj.org/toc/1687-9260; https://doaj.org/toc/1687-9279 |
| DOI: | 10.1155/2012/580814 |
| URL الوصول: | https://doaj.org/article/2c5a55b119ac482cbab259cb7a740320 |
| رقم الأكسشن: | edsdoj.2c5a55b119ac482cbab259cb7a740320 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16879260 16879279 |
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| DOI: | 10.1155/2012/580814 |