دورية أكاديمية
Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment
| العنوان: | Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment |
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| المؤلفون: | Bo Deng, Bing Ma, Yingying Ma, Pei Cao, Xigang Leng, Pengyu Huang, Yuanyuan Zhao, Tianjiao Ji, Xueguang Lu, Lanxia Liu |
| المصدر: | Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-14 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Nanoparticle, Co-delivery, Triggered release, CpG, Cancer immunotherapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Chemotherapeutics that can trigger immunogenic cell death (ICD) and release tumor-specific antigens are effective on treating a variety of cancers. The codelivery of chemotherapeutics with adjuvants is a promising strategy to achieve synergistic therapeutic effect. However, low drug loading and complicated preparation of current delivery systems lead to carrier-associated toxicity and immunogenicity. Herein, we developed a facile approach to construct liposomal spherical nucleic acids (SNA) by the self-assembly of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)-doxorubicin conjugate and DOPE-matrix metalloproteinases-9 (MMP-9) responsive peptide-CpG conjugate (DOPE-MMP-CpG). Liposomal SNAs efficiently co-delivered DOX and CpG into tumors and released the two drugs upon biological stimuli of MMP-9 enzyme in tumor microenvironment (TME) and high concentration of endogenous glutathione in tumor cells. We demonstrated that liposomal SNA enhanced activation of dendritic cells (DCs), promoted expansion of CD8+ and CD4+ T cells in both tumors and spleen, inhibited tumor growth, and extended animal survival. This work provided a simple strategy of delivering chemotherapeutics and adjuvants to tumors with synergistic therapeutic effect and reduced side effect. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-022-01353-5 |
| URL الوصول: | https://doaj.org/article/2c883afa910c405bac4fae936fbb2856 |
| رقم الأكسشن: | edsdoj.2c883afa910c405bac4fae936fbb2856 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-022-01353-5 |