دورية أكاديمية
New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy
| العنوان: | New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy |
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| المؤلفون: | Aleksandra Majchrzak-Celińska, Elżbieta Studzińska-Sroka |
| المصدر: | Molecules, Vol 29, Iss 7, p 1682 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | phytocompounds, glioblastoma, chemosensitization, phyto-nanoformulations, clinical trials, Organic chemistry, QD241-441 |
| الوصف: | Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, the current focus on phytocompound-based immunotherapy, or the use of phytocompounds as photosensitizers in photodynamic therapy. Moreover, we present new, intensively evaluated approaches, such as chemical modifications of phytochemicals or encapsulation into numerous types of nanoformulations, to improve their bioavailability and delivery to the brain. Finally, we present the clinical trials evaluating the role of phytocompounds or phytocompound-derived drugs in glioblastoma therapy and the less studied phytocompounds or plant extracts that have only recently been found to possess promising anti-glioblastoma properties. Overall, recent advancements in phytocompound research are encouraging; however, only with more 3D glioblastoma models, in vivo studies, and clinical trials it is possible to upgrade the role of phytocompounds in glioblastoma treatment to a satisfactory level. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 29071682 1420-3049 |
| Relation: | https://www.mdpi.com/1420-3049/29/7/1682; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules29071682 |
| URL الوصول: | https://doaj.org/article/2ca50b9f60274b40856a1b0dcb4d462c |
| رقم الأكسشن: | edsdoj.2ca50b9f60274b40856a1b0dcb4d462c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 29071682 14203049 |
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| DOI: | 10.3390/molecules29071682 |